×
Entrez Id:
107075310
Gene Symbol:
MTCO2P12
MTCO2P12
Primary malignant neoplasm of lung
0.100
Biomarker
BEFREE
Inhibition of mPGES-1 or COX-2 Results in Different Proteomic and Lipidomic Profiles in A549 Lung Cancer Cells.
31231223
2019
×
Entrez Id:
107075310
Gene Symbol:
MTCO2P12
MTCO2P12
Primary malignant neoplasm of lung
0.100
Biomarker
BEFREE
Inhibition of COX-2 and EGFR by Melafolone Improves Anti-PD-1 Therapy through Vascular Normalization and PD-L1 Downregulation in Lung Cancer .
30591531
2019
×
Entrez Id:
107075310
Gene Symbol:
MTCO2P12
MTCO2P12
Primary malignant neoplasm of lung
0.100
GeneticVariation
BEFREE
COX-2 rs5275 and rs689466 polymorphism and risk of lung cancer : A PRISMA-compliant meta-analysis.
30170377
2018
×
Entrez Id:
107075310
Gene Symbol:
MTCO2P12
MTCO2P12
Primary malignant neoplasm of lung
0.100
AlteredExpression
BEFREE
All isolates were in vitro evaluated for their cytotoxic activity against seven lung cancer cell lines, in addition to antimicrobial activity for eight bacteria, scavenging potential using ABTS<sup>·+</sup> and DPPH test, and anti-inflammatory activity for Cox-1 and Cox-2 which had not previously been tested for crinane-type alkaloids with the cleavage between C-1 and C-13.
30114468
2018
×
Entrez Id:
107075310
Gene Symbol:
MTCO2P12
MTCO2P12
Primary malignant neoplasm of lung
0.100
Biomarker
BEFREE
The THP-1, monocytic leukemia cell line effectively absorbed COX-2 by lung cancer cell-derived exosomes.
29345286
2018
×
Entrez Id:
107075310
Gene Symbol:
MTCO2P12
MTCO2P12
Primary malignant neoplasm of lung
0.100
AlteredExpression
BEFREE
Tissue microarray immunohistochemical analysis was performed to assess the correlation between NMI and COX-2 expression in lung cancer patients.
29025423
2017
×
Entrez Id:
107075310
Gene Symbol:
MTCO2P12
MTCO2P12
Primary malignant neoplasm of lung
0.100
AlteredExpression
BEFREE
BPA induced COX-2 expression via nuclear translocation of NF-κB and activation of mitogen-activated protein kinase (MAPK) by phosphorylation of ERK1/2 and enhanced the migration of lung cancer A549 and breast cancer MDAMB-231 cells.
28709031
2017
×
Entrez Id:
107075310
Gene Symbol:
MTCO2P12
MTCO2P12
Primary malignant neoplasm of lung
0.100
Biomarker
BEFREE
Further investigations showed that the PI3K/Akt signalling pathway and COX-2 are involved in endothelial tube formation under the stimulation of lung cancer cells.
28173828
2017
×
Entrez Id:
107075310
Gene Symbol:
MTCO2P12
MTCO2P12
Primary malignant neoplasm of lung
0.100
Biomarker
BEFREE
In this study, we showed that IGFBP-4 could decrease COX-2 production in lung cancer A549 cells.
28150906
2017
×
Entrez Id:
107075310
Gene Symbol:
MTCO2P12
MTCO2P12
Primary malignant neoplasm of lung
0.100
Biomarker
BEFREE
MiR-26b suppresses tumor cell proliferation, migration and invasion by directly targeting COX-2 in lung cancer .
26744864
2015
×
Entrez Id:
107075310
Gene Symbol:
MTCO2P12
MTCO2P12
Primary malignant neoplasm of lung
0.100
GeneticVariation
BEFREE
CONCLUSIONS In COX-2 gene, rs20417 may have a certain relationship with reduced risk of lung cancer , while rs2066826 may increase the risk of lung cancer .
26624903
2015
×
Entrez Id:
107075310
Gene Symbol:
MTCO2P12
MTCO2P12
Primary malignant neoplasm of lung
0.100
Biomarker
BEFREE
In the present study, the ability of meloxicam, a COX-2 -specific inhibitor to enhance doxorubicin‑mediated inhibition was investigated in human A549 lung cancer in vivo and in vitro.
26600514
2015
×
Entrez Id:
107075310
Gene Symbol:
MTCO2P12
MTCO2P12
Primary malignant neoplasm of lung
0.100
Biomarker
BEFREE
Thus, COX-2 is likely important in lung tumorigenesis, and COX-2 and its product, PGE2, are potential targets for lung cancer prevention.
26452035
2015
×
Entrez Id:
107075310
Gene Symbol:
MTCO2P12
MTCO2P12
Primary malignant neoplasm of lung
0.100
Biomarker
BEFREE
Role of LKB1-CRTC1 on glycosylated COX-2 and response to COX-2 inhibition in lung cancer .
25465874
2015
×
Entrez Id:
107075310
Gene Symbol:
MTCO2P12
MTCO2P12
Primary malignant neoplasm of lung
0.100
Biomarker
BEFREE
Our study provides pharmacological evidence that CS-6 exhibits potential use in the treatment of COX-2 -mediated diseases such as lung cancer .
25175164
2014
×
Entrez Id:
107075310
Gene Symbol:
MTCO2P12
MTCO2P12
Primary malignant neoplasm of lung
0.100
AlteredExpression
BEFREE
Interestingly, COX-2 is overexpressed in numerous cancers, including lung cancer .
25047043
2014
×
Entrez Id:
107075310
Gene Symbol:
MTCO2P12
MTCO2P12
Primary malignant neoplasm of lung
0.100
AlteredExpression
BEFREE
Moreover, downregulation of COX-2 /PGE2 and MIG-7 significantly prolonged the overall and disease-free survival of lung cancer -bearing mice.
25004182
2014
×
Entrez Id:
107075310
Gene Symbol:
MTCO2P12
MTCO2P12
Primary malignant neoplasm of lung
0.100
AlteredExpression
BEFREE
Upregulation of COX-2 in the lung cancer promotes overexpression of multidrug resistance protein 4 (MRP4) via PGE2-dependent pathway.
24909729
2014
×
Entrez Id:
107075310
Gene Symbol:
MTCO2P12
MTCO2P12
Primary malignant neoplasm of lung
0.100
AlteredExpression
BEFREE
Cyclooxygenase (COX) converts arachidonic acid to prostanoids, and increased expression of its isoform, COX‑2 , has been observed in lung cancer tissue.
24337484
2014
×
Entrez Id:
107075310
Gene Symbol:
MTCO2P12
MTCO2P12
Primary malignant neoplasm of lung
0.100
AlteredExpression
BEFREE
TGF-β1 downregulates COX-2 expression leading to decrease of PGE2 production in human lung cancer A549 cells, which is involved in fibrotic response to TGF-β1.
24098479
2013
×
Entrez Id:
107075310
Gene Symbol:
MTCO2P12
MTCO2P12
Primary malignant neoplasm of lung
0.100
Biomarker
BEFREE
Induction but not inhibition of COX-2 confers human lung cancer cell apoptosis by celecoxib.
23943857
2013
×
Entrez Id:
107075310
Gene Symbol:
MTCO2P12
MTCO2P12
Primary malignant neoplasm of lung
0.100
Biomarker
BEFREE
p38 MAPK, ERK, and COX-2 activation are novel mediators for the galectin-1-promoted tumor progression and chemoresistance in lung cancer .
22696230
2012
×
Entrez Id:
107075310
Gene Symbol:
MTCO2P12
MTCO2P12
Primary malignant neoplasm of lung
0.100
GeneticVariation
BEFREE
Taken together, this meta-analysis suggests that the COX 2 T8473C polymorphism is not associated with lung cancer risk.
22292629
2011
×
Entrez Id:
107075310
Gene Symbol:
MTCO2P12
MTCO2P12
Primary malignant neoplasm of lung
0.100
GeneticVariation
BEFREE
TNF-α 308G/A , IL-6 174G/C , IL-1β 31T/C , IL-1β 511C/T , COX-2 8473T/C polymorphisms were not detected to be related to the risk for LC .
22160576
2012
×
Entrez Id:
107075310
Gene Symbol:
MTCO2P12
MTCO2P12
Primary malignant neoplasm of lung
0.100
AlteredExpression
BEFREE
However, the regulatory mechanism underlying COX-2 overexpression in lung cancer is not fully understood.
21678473
2011